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While weight loss medications will help you with your weight loss journey, you will still need to follow a healthier diet and exercise routine to see sustainable results

This phenomenon is especially common with rapid weight loss, whether through lifestyle changes, bariatric surgery, or medications like semaglutide or tirzepatide

Gastrointestinal Adverse Reactions In the pool of placebo-controlled trials, gastrointestinal adverse reactions occurred more frequently among patients who received semaglutide tablets than placebo: semaglutide tablets 14 mg once daily (41%), semaglutide tablets 7 mg once daily (32%) and placebo (21%), including severe reactions (semaglutide tablets 14 mg 2.0%, semaglutide tablets 7 mg 0.6%, placebo 0.3%)

Working with Your Healthcare Provider If you are unsure whether semaglutide is causing your leg cramps, the best thing to do is talk to your healthcare provider